Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres

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Cremers, H.F.M. and Verrijk, R. and Noteborn, H.P.J.M. and Kwon, G. and Bae, Y.H. and Kim, S.W. and Feijen, J. (1994) Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. Journal of Controlled Release, 29 (1-2). pp. 143-155. ISSN 0168-3659

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Abstract:Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
Item Type:Article
Copyright:© 1994 Elsevier Science
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/9743
Official URL:http://dx.doi.org/10.1016/0168-3659(94)90130-9
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Metis ID: 105315