Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres

Cremers, H.F.M. and Verrijk, R. and Noteborn, H.P.J.M. and Kwon, G. and Bae, Y.H. and Kim, S.W. and Feijen, J. (1994) Adriamycin loading and release characteristics of albumin-heparin conjugate microspheres. Journal of Controlled Release, 29 (1-2). pp. 143-155. ISSN 0168-3659

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Abstract:	Biodegradable ion-exchange microspheres, prepared from a prefabricated conjugate of albumin and heparin were investigated as carriers for adriamycin. The ion-exchange microspheres could be loaded with adriamycin giving payloads up to 33% w/w, depending on the heparin content of the conjugate. In vitro adriamycin release depended on the ionic strength of the release medium. In ion containing media, for instance saline, 90% of the drug was released within 45 min, whereas in non-ionic media, such as distilled water, only 30% was released. Drug release profiles could be modelled by combining ion-exchange kinetics and diffusion controlled drug release models.
Item Type:	Article
Copyright:	© 1994 Elsevier Science
Faculty:	Science and Technology (TNW)
Research Group:	Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/9743
Official URL:	http://dx.doi.org/10.1016/0168-3659(94)90130-9
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