Tissue compatibility of poly(hydroxypropylglutamate)-prazosin conjugates

Li, Xiaoling and Kim, Sung Wan and Feijen, Jan and Yamaguchi, Kazuhiro and Anderson, James M. (1992) Tissue compatibility of poly(hydroxypropylglutamate)-prazosin conjugates. Journal of Controlled Release, 22 (3). pp. 181-196. ISSN 0168-3659

Preview

PDF
1881Kb

Abstract:	Biocompatibility of an injectable biodegradable drug delivery system for prazosin was investigated in Sprague-Dawley rats by histological studies after subcutaneous injection ofpoly(hydroxypropyl glutamate)-prazosin (PHPG-prazosin) conjugate particles. The studies showed that (1) the acute inflammatory response to this injectable biodegradable polymeric prodrug system was mild and of only short duration, (2) the chronic inflammation was minimal to zero, (3) the fibrous capsule could be seen starting from 7 days and became more prominent at longer time periods, (4) a collagen network was formed into the injection site after 21 days, (5) the macrophages and foreign giant cells reacted to the globules of conjugate particles, and (6) no adverse reactions were identified. Focal inflammation and the formation of the fibrous capsule around the injection site were the significant histological findings in the histopathological studies. Therefore, it is concluded that the biodegradable injectable PHPG-prazosin carbamate polymeric prodrug system is tissue biocompatible.
Item Type:	Article
Copyright:	© 1992 Elsevier Science
Faculty:	Science and Technology (TNW)
Research Group:	Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/9637
Official URL:	http://dx.doi.org/10.1016/0168-3659(92)90093-7
Export this item as:	BibTeX EndNote HTML Citation Reference Manager

Show download statistics for this publication

Repository Staff Only: item control page

Metis ID: 105262