Surface modification of hydrophobic polymers for improvement of endothelial cell-surface interactions


Dekker, A. and Reitsma, K. and Beugeling, T. and Bantjes, A. and Feijen, J. and Kirkpatrick, C.J. and Aken, W.G. van (1992) Surface modification of hydrophobic polymers for improvement of endothelial cell-surface interactions. Clinical Materials, 11 (1-4). pp. 157-162. ISSN 0267-6605

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Abstract:The aim of this study is to improve the interaction of endothelial cells with polymers used in vascular prostheses. Polytetrafluoroethylene (PTFE; Teflon) films were treated by means of nitrogen and oxygen plasmas. Depending on the plasma exposure time, modified PTFE surfaces showed water-contact angles of 15¿58° versus 96° for unmodified PTFE. Electron spectroscopy in chemical analysis (ESCA) measurements revealed incorporation of both nitrogenand oxygen-containing groups into the PTFE surfaces, dependent on the plasma composition and exposure time. In-vitro biological evaluation of unmodified and modified PTFE surfaces showed that human endothelial cells, seeded from 20% human serum-containing culture medium, adhered well on to modified PTFE surfaces, but not on to unmodified films. Adhesion of endothelial cells on to expanded PTFE graft material (Gore-Tex) was also stimulated by plasma treatment of this substrate. On plasma-treated expanded PTFE, the adhering endothelial cells formed a monolayer, which covered the textured surface. The latter observation is important in view of the hemocompatibility of vascular grafts seeded with endothelial cells before implantation.
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Copyright:© 1992 Elsevier Science
Science and Technology (TNW)
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