Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool

Share/Save/Bookmark

Vandersteen, A. and Masman, M.F. and Baets, G. de and Jonckheere, W. and Werf, K.O. van der and Marrink, S.J. and Rozenski, J. and Benilova, I. and Strooper, B. and Subramaniam, V. and Schymkowitz, J. and Rousseau, F. and Broersen, K. (2012) Molecular plasticity regulates oligomerization and cytotoxicity of the multi-peptide length Abeta pool. Journal of biological chemistry, 287 (44). 36732 - 36743. ISSN 0021-9258

[img] PDF
Restricted to UT campus only
: Request a copy
3MB
Abstract:Current therapeutic approaches under development for Alzheimer disease, including γ-secretase modulating therapy, aim at increasing the production of Aβ1–38 and Aβ1–40 at the cost of longer Aβ peptides. Here, we consider the aggregation of Aβ1–38 and Aβ1–43 in addition to Aβ1–40 and Aβ1–42, in particular their behavior in mixtures representing the complex in vivo Aβ pool. We demonstrate that Aβ1–38 and Aβ1–43 aggregate similar to Aβ1–40 and Aβ1–42, respectively, but display a variation in the kinetics of assembly and toxicity due to differences in short timescale conformational plasticity. In biologically relevant mixtures of Aβ, Aβ1–38 and Aβ1–43 significantly affect the behaviors of Aβ1–40 and Aβ1–42. The short timescale conformational flexibility of Aβ1–38 is suggested to be responsible for enhancing toxicity of Aβ1–40 while exerting a cyto-protective effect on Aβ1–42. Our results indicate that the complex in vivo Aβ peptide array and variations thereof is critical in Alzheimer disease, which can influence the selection of current and new therapeutic strategies
Item Type:Article
Copyright:© 2012 by American Society for Biochemistry and Molecular Biology
Faculty:
Science and Technology (TNW)
Link to this item:http://purl.utwente.nl/publications/81968
Official URL:http://dx.doi.org/10.1074/jbc.M112.394635
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 288675