Poly(ethylene glycol)-poly(L -lactide) star block copolymer hydrogels crosslinked by metal-ligand coordination

Share/Save/Bookmark

Buwalda, S.J. and Dijkstra, P.J. and Feijen, J. (2012) Poly(ethylene glycol)-poly(L -lactide) star block copolymer hydrogels crosslinked by metal-ligand coordination. Journal of polymer science. Part A: Polymer chemistry, 50 (9). 1783 - 1791. ISSN 0887-624X

[img]PDF
Restricted to UT campus only
: Request a copy
1050Kb
Abstract:The aqueous solution behavior and thermoreversible gelation properties of pyridine-end-functionalized poly(ethylene glycol)–poly(L-lactide) (PEG–(PLLA)8–py) star block copolymers in the presence of coordinating transition metal ions were studied. In aqueous solutions, the macromonomers self-assembled into micelles and micellar aggregates at low concentrations and formed physically crosslinked, thermoreversible hydrogels above a critical gel concentration (CGC) of 8% w/v. In the presence of transition metal ions like Cu(II), Co(II), or Mn(II), the aggregate dimensions increased. Above the CGC, the gel–sol transition shifted to higher temperatures due to the formation of additional crosslinks from intermolecular coordination complexes between metal ions and pyridine ligands. Furthermore, as an example, PEG–(PLLA)8–py hydrogels stabilized by Mn(II)–pyridine coordination complexes were more resistant against degradation/dissolution when placed in phosphate buffered saline at 37 °C when compared with hydrogels prepared in water. Importantly, the stabilizing effect of metal–ligand coordination was noticeable at very low Cu(II) concentrations, which have been reported to be noncytotoxic for fibroblasts in vitro. These novel PEG–(PLLA)8–py metallo-hydrogels, which are the first systems to combine metal–ligand coordination with the advantageous properties of PEG–PLLA copolymer hydrogels, are appealing materials that may find use in biomedical as well as environmental applications like the removal of heavy metal ions from waste streams
Item Type:Article
Copyright:© Wiley
Faculty:
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/81901
Official URL:http://dx.doi.org/10.1002/pola.25945
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 288523