Polymeric carrier systems for siRNA delivery

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Vader, P. and Aa, L.J. van der and Storm, G. and Schiffelers, R.M. and Engbersen, J.F.J. (2012) Polymeric carrier systems for siRNA delivery. Current topics in medicinal chemistry, 12 . 108 - 119. ISSN 1568-0266

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Abstract:Abstract

RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application
Item Type:Article
Additional information:Review article
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/81836
Official URL:http://dx.doi.org/10.2174/156802612798919123
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Metis ID: 288457