A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

Tijink, M.S.L. and Wester, M. and Sun, J. and Saris, A. and Bolhuis-Versteeg, L.A.M. and Saiful, S. and Joles, J.A. and Borneman, Z. and Wessling, M. and Stamatialis, D. (2012) A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step. Acta biomaterialia, 8 (6). 2279 - 2287. ISSN 1742-7061

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Abstract:	Hemodialysis is a commonly used blood purification technique in patients requiring kidney replacement therapy. Sorbents could increase uremic retention solute removal efficiency but, because of poor biocompatibility, their use is often limited to the treatment of patients with acute poisoning. This paper proposes a novel membrane concept for combining diffusion and adsorption of uremic retention solutes in one step: the so-called mixed-matrix membrane (MMM). In this concept, adsorptive particles are incorporated in a macro-porous membrane layer whereas an extra particle-free membrane layer is introduced on the blood-contacting side of the membrane to improve hemocompatibility and prevent particle release. These dual-layer mixed-matrix membranes have high clean-water permeance and high creatinine adsorption from creatinine model solutions. In human plasma, the removal of creatinine and of the protein-bound solute para-aminohippuric acid (PAH) by single and dual-layer membranes is in agreement with the removal achieved by the activated carbon particles alone, showing that under these experimental conditions the accessibility of the particles in the MMM is excellent. This study proves that the combination of diffusion and adsorption in a single step is possible and paves the way for the development of more efficient blood purification devices, excellently combining the advantages of both techniques.
Item Type:	Article
Copyright:	© 2012 Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Biomaterials Science and Technology (BST) Membrane Science and Technology (MST)
Link to this item:	http://purl.utwente.nl/publications/81725
Official URL:	http://dx.doi.org/10.1016/j.actbio.2012.03.008
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