Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins

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Jansen, Janine and Tibbe, M.P. and Mihov, G. and Feijen, J. and Grijpma, D.W. (2012) Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins. Acta biomaterialia, 8 (10). 3652 - 3659. ISSN 1742-7061

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Abstract:Photo-crosslinked networks were prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone. Two model proteins, lysozyme and albumin, were incorporated into the network films as solid particles and their release behavior was studied. By varying the NVP content and macromer molecular weight the degradation behavior and protein release profiles of the prepared networks could be tuned. The more hydrophilic and less densely crosslinked networks released albumin and lysozyme at a faster rate. Although active lysozyme was released from the networks over the complete release period, lysozyme release was often incomplete. This was most likely caused by electrostatic and/or hydrophobic interactions between the protein and the degrading polymer network.
Item Type:Article
Copyright:© 2012 Elsevier
Faculty:
Science and Technology (TNW)
Link to this item:http://purl.utwente.nl/publications/81686
Official URL:http://dx.doi.org/10.1016/j.actbio.2012.06.011
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