Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins

Jansen, Janine and Tibbe, M.P. and Mihov, G. and Feijen, J. and Grijpma, D.W. (2012) Photo-crosslinked networks prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone for the controlled and sustained release of proteins. Acta biomaterialia, 8 (10). 3652 - 3659. ISSN 1742-7061

PDF
Restricted to UT campus only: Request a copy
1053Kb

Abstract:	Photo-crosslinked networks were prepared from fumaric acid monoethyl ester-functionalized poly(d,l-lactic acid) oligomers and N-vinyl-2-pyrrolidone. Two model proteins, lysozyme and albumin, were incorporated into the network films as solid particles and their release behavior was studied. By varying the NVP content and macromer molecular weight the degradation behavior and protein release profiles of the prepared networks could be tuned. The more hydrophilic and less densely crosslinked networks released albumin and lysozyme at a faster rate. Although active lysozyme was released from the networks over the complete release period, lysozyme release was often incomplete. This was most likely caused by electrostatic and/or hydrophobic interactions between the protein and the degrading polymer network.
Item Type:	Article
Copyright:	© 2012 Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Polymer Chemistry and Biomaterials (PBM) Biomaterials Science and Technology (BST)
Link to this item:	http://purl.utwente.nl/publications/81686
Official URL:	http://dx.doi.org/10.1016/j.actbio.2012.06.011
Export this item as:	BibTeX EndNote HTML Citation Reference Manager

Show download statistics for this publication

Repository Staff Only: item control page

Metis ID: 288314