Pre-clinical validation of bone tissue engineering using mesenchymal stromal cells


Chatterjea, A. (2012) Pre-clinical validation of bone tissue engineering using mesenchymal stromal cells. thesis.

open access
Abstract:The incidence of bone and joint related disorders such as osteoporosis,
arthritis, as well as other diseases such as obesity, diabetes, and cancer, which
can cause injury to orthopedic tissues and affect the health and capability of
the human skeleton is on the rise. In such situations, the body’s own
regenerative capacities are often exceeded resulting in poor healing of bony
defects. Such situations necessitate the use of grafting material to aid the body
in its restorative attempts. It has been estimated that globally, one million
bone-grafting procedures are performed annually on the pelvis, spine, and
other body extremities. 11% of these procedures rely on the use of synthetic
bone graft substitutes. According to market analysis this number is expected
to rise even further in the coming years due to the aging population, lifestyle
issues, risks associated with obtaining autograft bone, the need to achieve
superior and optimum bone fusion, speedy patient recovery and the need to
eliminate multiple surgeries (in case of bone harvesting from the patient). The
challenge is to provide these synthetic substitutes with osteoconductive and
osteoinductive properties comparable to autologous bone. While altering the
physical and chemical properties of the synthetic graft materials has been
partially successful in endowing them with the desirable osteoinductive and
conductive properties, till date their performance within the human body is
not comparable to that of autologous bone. Adding growth factors such as
bone morphogenetic proteins (BMPs) and stem cells have been proposed as
alternative strategies to boost the biological properties of these materials. In
this thesis, we have mainly focused on optimizing the combination of ceramic
materials with stem cells derived from the adult bone marrow (BM derived
MSCs) to engineer a bone graft which has potential to be used clinically as a
replacement for autografts.
Item Type:Thesis
Science and Technology (TNW)
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