Osteoinductive ceramics as a synthetic alternative to autologous bone grafting

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Yuan, Huipin and Fernandes, Hugo and Habibovic, Pamela and Boer, Jan de and Barradas, Ana M.C. and Ruiter, Ad de and Walsh, William R. and Blitterswijk, Clemens A. van and Bruijn, Joost D. de (2010) Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. Proceedings of the National Academy of Sciences of the United States of America, PNAS, 107 (31). pp. 13614-13619. ISSN 0027-8424

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Abstract:Biomaterials can be endowed with biologically instructive properties by changing basic parameters such as elasticity and surface texture. However, translation from in vitro proof of concept to clinical application is largely missing. Porous calcium phosphate ceramics are used to treat small bone defects but in general do not induce stem cell differentiation, which is essential for regenerating large bone defects. Here, we prepared calcium phosphate ceramics with varying physicochemical and structural characteristics. Microporosity correlated to their propensity to stimulate osteogenic differentiation of stem cells in vitro and bone induction in vivo. Implantation in a large bone defect in sheep unequivocally demonstrated that osteoinductive ceramics are equally efficient in bone repair as autologous bone grafts. Our results provide proof of concept for the clinical application of “smart” biomaterials.
Item Type:Article
Copyright:© 2012 National Academy of Sciences of the United States of America
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/80663
Official URL:http://dx.doi.org/10.1073/pnas.1003600107
Supplementary information URL:http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1003600107/-/DCSupplemental
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