'Smart' biomaterials and osteoinductivity

Yuan, Huipin and Fernandes, Hugo and Habibovic, Pamela and Boer de, Jan and Barradas, Ana M.C. and Ruiter de, Ad and Walsh, William R. and Blitterswijk van, Clemens A. and Bruijn de, Joost D. (2011) 'Smart' biomaterials and osteoinductivity. Nature Reviews Rheumatology, 7 . c1 - . ISSN 1759-4790

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Abstract:	In their recent paper in Nature Reviews Rheumatology, Boyan and Schwartz discussed the use of synthetic biomaterials in repair strategies of large bone defects (Are calcium phosphate ceramics 'smart' biomaterials?Nat. Rev. Rheumatol. 7, 8–9; 2011).1 This News & Views commentary, which is largely based on our publication in the Proceedings of the National Academy of Sciences,2 justly emphasizes the importance of the search for alternatives to autologous bone grafts, which are limited in availability, for treatment of large bone defects. Boyan and Schwartz question if calcium phosphate ceramics are indeed 'smart' biomaterials, in the sense of being truly osteoinductive. Referring to our work they state: “...unfortunately, however, it is not clear whether the intramuscular implants used in the dog and sheep models were only the porous ceramics or if they were the composite grafts with human mesenchymal stem cells (hMSCs) that had been pre-differentiated in osteogenic medium”.1 We would like to explicitly emphasize and clarify that the referred data were obtained by using ceramics alone, without the addition of any cells and/or growth factors.
Item Type:	Article
Copyright:	© 2011 Nature Publishing Group
Faculty:	Science and Technology (TNW)
Research Group:	Tissue Regeneration (TR) Biomechanical Engineering (BE) Biomaterials Science and Technology (BST)
Link to this item:	http://purl.utwente.nl/publications/80642
Official URL:	http://dx.doi.org/10.1038/nrrheum.2010.210-c1
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