Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels


Jin, Rong and Moreira Teixeira, Liliana S. and Dijkstra, Pieter J. and Blitterswijk, Clemens A. van and Karperien, Marcel and Feijen, Jan (2011) Chondrogenesis in injectable enzymatically crosslinked heparin/dextran hydrogels. Journal of Controlled Release, 152 (1). pp. 186-195. ISSN 0168-3659

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Abstract:In this study, injectable hydrogels were prepared by horseradish peroxidase-mediated co-crosslinking of dextran–tyramine (Dex–TA) and heparin–tyramine (Hep–TA) conjugates and used as scaffolds for cartilage tissue engineering. The swelling and mechanical properties of these hydrogels can be easily controlled by the Dex–TA/Hep–TA weight ratio. When chondrocytes were incorporated in these gels, cell viability and proliferation were highest for gels with a 50/50 weight ratio of Dex–TA/Hep–TA. Moreover, these hydrogels induced an enhanced production of chondroitin sulfate and a more abundant presence of collagen as compared to Dex–TA hydrogels. The results indicate that injectable Dex–TA/Hep–TA hydrogels are promising scaffolds for cartilage regeneration.
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Copyright:© 2011 Elsevier
Science and Technology (TNW)
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Metis ID: 283833