Tissue deformation spatially modulates VEGF signaling and angiogenesis

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Rivron, Nicolas C. and Vrij, Erik J. and Rouwkema, Jeroen and Le Gac, Severine and Berg, Albert van den and Truckenmuller, Roman K. and Blitterswijk, Clemens A. van (2012) Tissue deformation spatially modulates VEGF signaling and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America, PNAS, 109 (18). pp. 6886-6891. ISSN 0027-8424

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Abstract:Physical forces play a major role in the organization of developing tissues. During vascular development, physical forces originating from a fluid phase or from cells pulling on their environment can alter cellular signaling and the behavior of cells. Here, we observe how tissue deformation spatially modulates angiogenic signals and angiogenesis. Using soft lithographic templates, we assemble three-dimensional, geometric tissues. The tissues contract autonomously, change shape stereotypically and form patterns of vascular structures in regions of high deformations. We show that this emergence correlates with the formation of a long-range gradient of Vascular Endothelial Growth Factor (VEGF) in interstitial cells, the local overexpression of the corresponding receptor VEGF receptor 2 (VEGFR-2) and local differences in endothelial cells proliferation. We suggest that tissue contractility and deformation can induce the formation of gradients of angiogenic microenvironments which could contribute to the long-range patterning of the vascular system.
Item Type:Article
Copyright:© 2012 National Academy of Sciences of the United States of America
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/80519
Official URL:http://dx.doi.org/10.1073/pnas.1201626109
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