Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins

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Seck, Tetsu M. and Melchels, Ferry P.W. and Feijen, Jan and Grijpma, Dirk W. (2010) Designed biodegradable hydrogel structures prepared by stereolithography using poly(ethylene glycol)/poly(d,l-lactide)-based resins. Journal of Controlled Release, 148 (1). pp. 34-41. ISSN 0168-3659

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Abstract:Designed three-dimensional biodegradable poly(ethylene glycol)/poly(d,l-lactide) hydrogel structures were prepared for the first time by stereolithography at high resolutions. A photo-polymerisable aqueous resin comprising PDLLA-PEG-PDLLA-based macromer, visible light photo-initiator, dye and inhibitor in DMSO/water was used to build the structures. Porous and non-porous hydrogels with well-defined architectures and good mechanical properties were prepared. Porous hydrogel structures with a gyroid pore network architecture showed narrow pore size distributions, excellent pore interconnectivity and good mechanical properties. The structures showed good cell seeding characteristics, and human mesenchymal stem cells adhered and proliferated well on these materials.
Item Type:Article
Copyright:© 2010 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/80283
Official URL:http://dx.doi.org/10.1016/j.jconrel.2010.07.111
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Metis ID: 272859