Bioreducible poly(amidoamine)s with charge-reversal properties for intracellular protein delivery

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Coué, Grégory and Engbersen, Johan F.J. (2010) Bioreducible poly(amidoamine)s with charge-reversal properties for intracellular protein delivery. Journal of Controlled Release, 148 (1). e9-e11. ISSN 0168-3659

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Abstract:An effective intracellular protein delivery system was developed using bioreducible disulfide-containing poly(amidoamine)s with negatively charged citraconic side groups that can give charge-reversal upon pH decrease. These water-soluble and linear polymers efficiently self-assemble with proteins into nanocomplexes by charge attraction. Intracellular-mimicking protein release from the particles is triggered by the reduction of polymer disulfide linkages, causing polymer degradation, and inversion of protein-polymer interaction at endosomal pH due to the charge-reversal of the citraconic side group.
Item Type:Article
Copyright:© 2010 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/80273
Official URL:http://dx.doi.org/10.1016/j.jconrel.2010.07.004
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