Bioreducible poly(amidoamine)s with charge-reversal properties for intracellular protein delivery

Coué, Grégory and Engbersen, Johan F.J. (2010) Bioreducible poly(amidoamine)s with charge-reversal properties for intracellular protein delivery. Journal of Controlled Release, 148 (1). e9-e11. ISSN 0168-3659

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Abstract:	An effective intracellular protein delivery system was developed using bioreducible disulfide-containing poly(amidoamine)s with negatively charged citraconic side groups that can give charge-reversal upon pH decrease. These water-soluble and linear polymers efficiently self-assemble with proteins into nanocomplexes by charge attraction. Intracellular-mimicking protein release from the particles is triggered by the reduction of polymer disulfide linkages, causing polymer degradation, and inversion of protein-polymer interaction at endosomal pH due to the charge-reversal of the citraconic side group.
Item Type:	Article
Copyright:	© 2010 Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Biomedical Chemistry (BMC)
Link to this item:	http://purl.utwente.nl/publications/80273
Official URL:	http://dx.doi.org/10.1016/j.jconrel.2010.07.004
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