Tissue assembly and organization: Developmental mechanisms in microfabricated tissues

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Rivron, Nicolas C. and Rouwkema, Jeroen and Truckenmüller, Roman and Karperien, Marcel and Boer de, Jan and Blitterswijk van, Clemens A. (2009) Tissue assembly and organization: Developmental mechanisms in microfabricated tissues. Biomaterials, 30 (28). pp. 4851-4858. ISSN 0142-9612

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Abstract:In vitro-generated tissues hold significant promise in modern biology since they can potentially mimic physiological and pathological tissues. However, these are currently structurally and functionally of limited complexity and necessitate self-organization and recapitulation of tissue development mechanisms in vitro. Tools derived from nano- and microfabrications along with bottom-up strategies are emerging to allow the fabrication of primitive tissues structures that can remodel overtime. Subsequently, clues are accumulating to show that, beyond genetic material, both intrinsic tissue architectures and microenvironmental cues can lead to morphogenesis related mechanisms in vitro. The question arises, however, as how we may design and assemble structures prone to adequate tissue remodeling, predict and manipulate those developmental mechanisms in vitro? Systems integrating architectural, physical and molecular cues will allow more systematic investigation of basic principles of tissue morphogenesis, differentiation or maintenance and will feedback to reproduce the dynamic of tissue development in vitro and form more complex tissues.
Item Type:Article
Copyright:© 2009 Elsevier
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/80086
Official URL:http://dx.doi.org/10.1016/j.biomaterials.2009.06.037
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