Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film

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Dam, Henk H. and Tomasberger, Tanja and Reinhoudt, David N. and Verboom, Willem (2008) Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film. Analytica Chimica Acta, 635 (1). pp. 79-83. ISSN 0003-2670

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Abstract:A screening method for parallel Am3+ ligand libraries is presented. The method makes use of α-radiation in combination with a photographic film to detect the complexed Am3+. After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am3+. This allows a fast discrimination between the Am3+ complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5 Bq 241Am can be detected. Using internal standards a semi-quantitative assessment can be performed.
Item Type:Article
Copyright:© 2008 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/79111
Official URL:http://dx.doi.org/10.1016/j.aca.2009.01.023
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