Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release


Lensen, Dennis and Gelderblom, Erik C. and Vriezema, Dennis M. and Marmottant, Philippe and Verdonschot, Nico and Versluis, Michel and Jong, Nico de and Hest, Jan C.M. van (2011) Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release. Soft Matter, 7177 . pp. 5417-5422. ISSN 1744-683X

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Abstract:A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion
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Copyright:© Royal Society of Chemistry
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