Combined optical and acoustical detection of single microbubble dynamics


Sijl, Jeroen and Vos, Hendrik J. and Rozendal, Timo and Jong, Nico de and Lohse, Detlef and Versluis, Michel (2011) Combined optical and acoustical detection of single microbubble dynamics. Journal of the Acoustical Society of America, 130 (5). pp. 3271-3281. ISSN 0001-4966

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Abstract:A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.
Item Type:Article
Additional information:Special issue on the acoustics of bubbles and cavitation
Copyright:© Acoustical Society of America
Science and Technology (TNW)
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