Biological performance in goats of a porous titanium alloy–biphasic calcium phosphate composite

Share/Save/Bookmark

Li, JiaPing and Habibovic, Pamela and Yuan, Huipin and Doel, Mirella van den and Wilson, Clayton E. and Wijn, Joost R. de and Blitterswijk, Clemens A. van and Groot, Klaas de (2007) Biological performance in goats of a porous titanium alloy–biphasic calcium phosphate composite. Biomaterials, 28 (29). pp. 4209-4218. ISSN 0142-9612

[img] PDF
Restricted to UT campus only
: Request a copy
1MB
Abstract:In this study, porous 3D fiber deposition titanium (3DFT) and 3DFT combined with porous biphasic calcium phosphate ceramic (3DFT+BCP) implants, both bare and 1 week cultured with autologous bone marrow stromal cells (BMSCs), were implanted intramuscularly and orthotopically in 10 goats. To assess the dynamics of bone formation over time, fluorochrome markers were administered at 3, 6 and 9 weeks and the animals were sacrificed at 12 weeks after implantation. New bone in the implants was investigated by histology and histomorphometry of non-decalcified sections. Intramuscularly, no bone formation was found in any of the 3DFT implants, while a very limited amount of bone was observed in 2 BMSC 3DFT implants. 3DFT+BCP and BMSC 3DFT+BCP implants showed ectopic bone formation, in 8 and 10 animals, respectively. The amount of formed bone was significantly higher in BMSC 3DFT+BCP as compared to 3DFT+BCP implants. Implantation on transverse processes resulted in significantly more bone formation in composite structure as compared to titanium alloy alone, both with and without cells. Unlike intramuscularly, the presence of BMSC did not have a significant effect on the amount of new bone either in metallic or in composite structure. Although the 3DFT is inferior to BCP for bone growth, the reinforcement of the brittle BCP with a 3DFT cage did not negatively influence osteogenesis, osteoinduction and osteoconduction as previously shown for the BCP alone. The positive effect of BMSCs was observed ectopically, while it was not significant orthotopically.
Item Type:Article
Copyright:© 2007 Elsevier
Faculty:
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/78877
Official URL:http://dx.doi.org/10.1016/j.biomaterials.2007.05.042
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 240726