The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis


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Ávila Muñoz, Mónica and Eijkel, Jan and Floris, Arjan and Staal, Steven and Ríos, Ángel and Berg, Albert van den (2011) The development of a point of care creatinine measurement using disposable ready to use microchip capillary electrophoresis. In: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011, 2-6 October 2011, Seattle, Washington (pp. pp. 1206-1208).

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Abstract:We report on the determination of creatinine in human serum using a point-of-care device suitable for the use by untrained operators, the Medimate Multireader®. This device is based on electrophoretic separation and conductivity detection and its prefilled microfluidic chip has a single opening for sample introduction. The device was originally developed for the determination of lithium in blood [1]. Creatinine determination at a level of quantification of 300 μM was realized by optimizing the background electrolyte (BGE) pH and concentration, and the injection and separation potentials and time. This limit of quantification is in the relevant range for the detection of renal failure [2].
Item Type:Conference or Workshop Item
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/78660
Related URL:http://www.microtas2011.org/
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