Concentration polarization in nanochannel DNA electrophoresis


Dubsky, Pavel and Das, Siddhartha and Berg, Albert van den and Eijkel, Jan C.T. (2011) Concentration polarization in nanochannel DNA electrophoresis. In: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2011, 2-6 October 2011, Seattle, Washington (pp. pp. 212-214).

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Abstract:We demonstrate that the large field electrophoresis of a single DNA molecule in nanofluidic systems is accompanied by concentration polarization. We illustrate this phenomena by utilizing our electrophoretic simulation tool SIMUL. First we in-vestigate a simple system with univalent strong electrolyte as a bulk solution. Second, a more complicated system with buf-fering background electrolyte is examined. Concentration polarization in the vicinity of the DNA is observed in both the sys-tems. The practical impact of such observations are also discussed.
Item Type:Conference or Workshop Item
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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