Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles

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Zhang, Zheng and Grijpma, Dirk W. and Feijen, Jan (2006) Thermo-sensitive transition of monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) films to micellar-like nanoparticles. Journal of Controlled Release, 112 (1). pp. 57-63. ISSN 0168-3659

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Abstract:Monomethoxy poly(ethylene glycol)-block-poly(trimethylene carbonate) (mPEG3–PTMC11, Mn of mPEG = 3.1 × 103 and Mn of PTMC = 10.8 × 103 g/mol) was synthesized by ring-opening polymerization of TMC using mPEG3 as an initiator and stannous octoate as a catalyst. The block copolymer has a broad melting range with a peak at 49.5 °C and a heat of fusion of 47.6 J/g. The heat of fusion normalized to the mPEG content is higher than that of the mPEG3 polymer, suggesting that PTMC segments are also semi-crystalline. The mPEG3–PTMC11 films were stable in water at room temperature, whereas at 37 °C the film specimens disintegrated and the amphiphilic block copolymer self-assembled into micellar-like nanoparticles with average sizes up to 210 nm. The critical association concentration (CAC) of the formed micellar-like particles is 1.35 × 10− 3 mg/ml. The average size and polydispersity index of the formed mPEG3–PTMC11 nanoparticles depend on temperature and storage time: the values decrease with increases in temperature and in storage time. By co-dissolving dexamethasone with mPEG3–PTMC11 during the film preparation, micellar-like nanoparticles loaded with dexamethasone can be obtained after the film to micellar-like nanoparticles transition. A high loading efficiency of 93.3 wt.% was achieved. The sustained release of the drug was complete in 20 d.
Item Type:Article
Copyright:© 2006 Elsevier
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/78482
Official URL:http://dx.doi.org/10.1016/j.jconrel.2006.01.010
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Metis ID: 236866