Analysing uncertainty around costs of innovative medical technologies: The case of fibrin sealant (QUIXIL®) for total knee replacement

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Steuten, Lotte and Vallejo-Torres, Laura and Bastide, Philippe and Buxton, Martin J. (2009) Analysing uncertainty around costs of innovative medical technologies: The case of fibrin sealant (QUIXIL®) for total knee replacement. Health Policy, 89 (1). pp. 46-57. ISSN 0168-8510

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Abstract:This paper presents a relatively simple cost model comparing the costs of using a commercial fibrin sealant (QUIXIL®) in addition to conventional haemostatic treatment vs. conventional treatment alone in total knee replacement (TKR) surgery, and demonstrates and discusses how one- and two-way sensitivity analyses can inform decisions regarding an innovative medical technology, for which there is limited evidence on economic parameters. The model synthesises data from various sources and assesses the proportion of individuals likely to need blood transfusion, the resource use after TKR and transfusion-related adverse events.

Whether using fibrin sealant is cost saving strongly depends on the amount used, the achieved reduction in hospital length of stay (LOS) and price of QUIXIL®. If a 10-ml dose of fibrin sealant is required to achieve the effects as described in the published trials, its use adds cost, but if 25% or more of patients are treated with a 5-ml dose, its use becomes cost saving for the NHS. The sensitivity analyses provide clear guidance regarding parameters for additional data collection; design of future trials; and product pricing in relation to its effectiveness, and are likely to be preferred over more sophisticated approaches to inform medical device decision-making, particularly at the local level.

Item Type:Article
Copyright:© Elsevier
Faculty:
Management and Governance (SMG)
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Link to this item:http://purl.utwente.nl/publications/78173
Official URL:http://dx.doi.org/10.1016/j.healthpol.2008.05.002
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