The HR2 Haplotype of Factor V Is not Associated with the Risk of Myocardial Infarction

Doggen, Carine J.M. and Visser de, Marieke C.H. and Vos, Hans L. and Bertina, Rogier M. and Manger Cats, Volkert and Rosendaal, Frits R. (2000)
The HR2 Haplotype of Factor V Is not Associated with the Risk of Myocardial Infarction. Thrombosis and Haemostasis, 84 (5). pp. 815-818. ISSN 0340-6245

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Abstract:	The HR2 haplotype of the factor V gene, which contains the histidineto arginine substitution at position 1299, has been reported to beassociated with reduced factor V levels. Because high factor V levelshave been found to be associated with an increased risk of myocardialinfarction, we examined how the presence of the R2 allele affected therisk of myocardial infarction in the case-control "Study of MyocardialInfarctions Leiden".Among 560 men with a first myocardial infarction before the age of70 years, 9.5% were heterozygous carriers of the R2 allele. The controlgroup consisted of 646 men, in which 9.9% were heterozygous and0.2% homozygous carriers of the R2 allele. The risk of myocardialinfarction in the presence of the R2 allele was not increased (odds ratio,0.9; 95% confidence interval 0.6 to 1.4). Exclusion of factor V Leidencarriers did not change this result. The risk was 4.4-fold increased forsmokers who carried the R2 allele compared to non-smoking non-carriers.No synergy was found between metabolic risk factors and thepresence of the R2 allele.We conclude that the risk of myocardial infarction for men in thepresence of the R2 allele of the His1299Arg polymorphism is neitherincreased nor decreased
Item Type:	Article
Copyright:	© Schattauer Publishers
Link to this item:	http://purl.utwente.nl/publications/77854
Official URL:	http://www.schattauer.de/de/magazine/uebersicht/zeitschriften-a-z/thrombosis-and-haemostasis/contents/archive/issue/891/manuscript/2587/show.html
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