Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction

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Psaty, B.M. and Doggen, C. and Vos, H.L. and Vandenbroucke, J.P. and Rosendaal, F.R. (2000) Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction. Journal of human hypertension, 14 (2). pp. 95-97. ISSN 0950-9240

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Abstract:Genetic variation in adducin, a protein associated with the inner leaflet of the plasma membrane, may be in part responsible for salt-sensitive hypertension. In the Netherlands, 560 men who survived a myocardial infarction and 646 men who had undergone an orthopaedic intervention participated in a case-control study. In men in this study, the -adducin polymorphism was not associated with the risk of myocardial infarction either among those with or among those without a clinical history of hypertension. In a cross-sectional analysis of blood pressure data from the controls, the -adducin polymorphism was associated neither with self-reported hypertension (OR = 0.78, 95% CI = 0.51-1.19) nor with mean levels of systolic or diastolic blood pressure. Additional studies in other populations are needed to assess the contribution of -adducin to high blood pressure and cardiovascular risk.

Item Type:Article
Link to this item:http://purl.utwente.nl/publications/77845
Official URL:http://www.nature.com/jhh/journal/v14/n2/abs/1000943a.html
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