Comorbidity and age affect treatment policy for cervical cancer: a population-based study in the south of The Netherlands, 1995-2004

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Aa van der, M.A. and Siesling, S. and Kruitwagen, R.F.P.M. and Lybeert, M.L.M. and Coebergh, J.W.W. and Janssen-Heijnen, M.L.G. (2008) Comorbidity and age affect treatment policy for cervical cancer: a population-based study in the south of The Netherlands, 1995-2004. European Journal of Gynaecological Oncology, 29 (5). pp. 493-498. ISSN 0392-2936

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Abstract:OBJECTIVE: The aim of this study was to estimate the effects of age and comorbidity on the choice of treatment modalities and prognosis for patients with cervical cancer. METHODS: All patients with cervical cancer newly diagnosed between 1995 and 2004 (n=775) were selected from the population-based Eindhoven Cancer Registry. Time trends in treatment modalities and differences in treatment between older and younger patients, and those with and without comorbidity were evaluated. RESULTS: Older patients with FIGO Stages IB-IIA, elderly and those with comorbidity underwent less surgery. In multivariate survival analysis, age had independent prognostic value. For patients with FIGO Stages IB2, IIB-IVA, age affected the choice of chemoradiation significantly. According to multivariate survival analysis, comorbidity and FIGO stage were independent prognostic factors. CONCLUSION: Older patients with cervical cancer and those with comorbidity were treated less aggressively. Because of the ever-increasing role of comorbidity in clinical decision-making for increasingly older patients in the near future, development of age-specific guidelines incorporating levels and management of specific comorbidity seems warranted
Item Type:Article
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Management and Governance (SMG)
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Link to this item:http://purl.utwente.nl/publications/77718
Official URL:http://www.irog.net/pdf/EuropeanJournal/Eur_imp_n_5_2008.pdf
Publisher URL:http://www.irog.net/en-CA/
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