Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma


Jobsen, J.J. and Lybeert, M.L.M. and Steen-Banasik, E.M. van der and Slot, A. and Palen, J. van der and Cate, L.N. ten and Scholten, A. and Coen, V. and Schutter, E.M. and Siesling, S. (2008) Multicenter cohort study on treatment results and risk factors in stage II endometrial carcinoma. International Journal of Gynecological Cancer, 18 (5). pp. 1071-1078. ISSN 1048-891X

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Abstract:The aim of this study was to report outcome data and prognostic factors from a large cohort of pathologic stage II endometrioid type endometrial carcinoma. One hundred forty-two stage IIA–B patients were included. A central histopathologic review was performed. Follow-up ranged from 2 to 217 months with a median of 61 months. End points of the study were local and locoregional recurrence rates, distant metastasis–free survival (DMFS), disease-free survival (DFS), and disease-specific survival (DSS). The local failure rate was 5.1% for stage IIA patients and 10.8% for stage IIB patients. Grade was the only significant prognostic factor for local failure. With respect to DMFS, DFS, and DSS, grade 3 showed to be the most prominent prognostic factor in multivariate analyses. Lymphvascular space involvement combined with grades 3 and 2 and myometrial invasion greater than 0.5 also showed to be significant for DMFS and DFS. Our study showed grade 3 to be the most important single independent predictive factor for locoregional and distant recurrences in endometrial carcinoma stage II
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