Automated myocardial perfusion from coronary X-ray angiography


Storm, Corstiaan J. and Slump, Cornelis H. (2010) Automated myocardial perfusion from coronary X-ray angiography. In: Nico Karssemeijer & Ronald M. Summers (Eds.), Medical Imaging 2010: Computer-Aided Diagnosis. Proceedings of SPIE, 7624 . SPIE, Bellingham, Washington, 76242S. ISBN 9780819480316

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Abstract:The purpose of our study is the evaluation of an algorithm to determine the physiological relevance of a coronary
lesion as seen in a coronary angiogram. The aim is to extract as much as possible information from a standard
coronary angiogram to decide if an abnormality, percentage of stenosis, as seen in the angiogram, results in
physiological impairment of the blood supply of the region nourished by the coronary artery. Coronary angiography,
still the golden standard, is used to determine the cause of angina pectoris based on the demonstration
of an important stenose in a coronary artery. Dimensions of a lesion such as length and percentage of narrowing
can at present easily be calculated by using an automatic computer algorithm such as Quantitative Coronary
Angiography (QCA) techniques resulting in just anatomical information ignoring the physiological relevance of
the lesion. In our study we analyze myocardial perfusion images in standard coronary angiograms in rest and
in artificial hyperemic phases, using a drug e.g. papaverine intracoronary. Setting a Region of Interest (ROI) in
the angiogram without overlying major vessels makes it possible to calculate contrast differences as a function of
time, so called time-density curves, in the basal and hyperemic phases. In minimizing motion artifacts, end diastolic
images are selected ECG based in basal and hyperemic phase in an identical ROI in the same angiographic
projection. The development of new algorithms for calculating differences in blood supply in the region as set
are presented together with the results of a small clinical case study using the standard angiographic procedure
Item Type:Book Section
Copyright:© 2010 COPYRIGHT SPIE--The International Society for Optical Engineering
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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