Biophotonic sensors on a microchip for trace-gas detection, DNA and enzyme analysis, Raman spectroscopy, and optical coherence tomography

Pollnau, M. and Akca, B.I. and Ismail, N. and Dongre, C. and Pham, S.V. and Wörhoff, K. and Ridder de, R.M. and Hoekstra, H.J.W.M. (2011) Biophotonic sensors on a microchip for trace-gas detection, DNA and enzyme analysis, Raman spectroscopy, and optical coherence tomography. In: Joint Annual Meeting of the Swiss Physical Society and the Austrian Physical Society, 15-17 June 2011, Lausanne, Switzerland.

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Abstract:	Use of optical principles for the detection and analysis of biomolecules and biotissue has a long-standing tradition, and highly sensitive optical methods have been developed. Integration on a microchip offers cost reduction and instrument miniaturization, thus enabling novel applications, but also allows reduced biosample volumes, higher sensitivity, and faster acquisition times. We demonstrate optical sensing with Bragg-grating cavities inscribed into optical waveguides for label-free sensing of antibody-antigen protein reactions and H2 gas sensing by stress-induced Pd-receptor microcantilever deflections. Furthermore, we introduce the method of modulation-frequency-encoded multi-wavelength fluorescent DNA analysis in an optofluidic chip during capillary electrophoresis separation, enabling detection down to the single-molecule level and allowing simultaneous analysis of DNA fragments from independent human genomic segments, associated with genetic predispositions to breast cancer and anemia, in a single experiment. Finally, by integrating wavelength-selective arrayed-waveguide gratings on a microchip, we demonstrate on-chip Raman spectroscopy and spectral-domain optical coherence tomography of biotissue.
Item Type:	Conference or Workshop Item
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS)
Research Group:	Integrated Optical MicroSystems (IOMS)
Link to this item:	http://purl.utwente.nl/publications/77565
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