The Relationship Between Exercise and Risk of Venous Thrombosis in Elderly People

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Stralen, Karlijn J. van and Doggen, Carine J.M. and Lumley, Thomas and Cushman, Mary and Folsom, Aaron R. and Psaty, Bruce M. and Siscovick, David and Rosendaal, Frits R. and Heckbert, Susan R. (2008) The Relationship Between Exercise and Risk of Venous Thrombosis in Elderly People. Journal of the American Geriatrics Society, 56 (3). pp. 517-522. ISSN 0002-8614

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Abstract:OBJECTIVES: To study whether exercise is associated with the risk of venous thrombosis in elderly people.

DESIGN: Observational study with a median follow-up of 11.6 years.

SETTING: The Cardiovascular Health Study in four U.S. communities.

PARTICIPANTS: People aged 65 and older without prior venous thrombosis (deep venous thrombosis or pulmonary embolism).

MEASUREMENTS: Self-reported exercise was measured two or three times during follow-up and was defined as expending more than 500 kcal/wk on exercise, including walking for exercise. Venous thrombosis cases were verified using medical record review.

RESULTS: Of 5,534 participants, 171 developed a first venous thrombosis. Self-reported exercise at baseline was not related to the risk of venous thrombosis after adjustment for sex, age, race, self-reported health, and body mass index (adjusted hazard ratio (HRadj)=1.16, 95% confidence interval (CI)=0.84–1.61), although with exercise modeled as a time-varying exposure, overall results were in the direction of greater risk of venous thrombosis (HRadj=1.38, 95% CI=0.99–1.91). For mild-intensity exercise, such as walking, there was a nonsignificant finding in the direction of benefit (HRadj=0.75, 95% CI=0.49–1.16), but strenuous exercise, such as jogging, was associated with greater risk of venous thrombosis (HRadj=1.75, 95% CI=1.08–2.83) than no exercise at all.

CONCLUSION: In elderly people, strenuous exercise was associated with a higher risk of venous thrombosis than no exercise at all. Future studies are needed to explain this unexpected higher risk.

Item Type:Article
Copyright:© 2008, Copyright the Authors; Journal compilation © 2008, The American Geriatrics Society
Link to this item:http://purl.utwente.nl/publications/76900
Official URL:http://dx.doi.org/10.1111/j.1532-5415.2007.01588.x
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