Spatial resolution of the inveon small-animal PET scanner for the entire field of view


Disselhorst, J.A. and Boerman, O.C. and Oyen, W.J.G. and Slump, C.H. and Visser, E.P. (2010) Spatial resolution of the inveon small-animal PET scanner for the entire field of view. Nuclear instruments and methods in physics research. Section A: Accelerators, spectrometers, detectors and associated equipment, 615 (2). pp. 245-248. ISSN 0168-9002

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Abstract:In high throughput small-animal positron emission tomography (PET) studies, it can be advantageous to scan more than one animal at the same time. To optimally position these animals in the scanner, both sensitivity and spatial resolution have to be known across the entire field of view (FOV). The Siemens Inveon small-animal PET scanner has been characterized according to NEMA NU 4-2008 standards, but the spatial resolution has only been determined in a small portion of the FOV and only for filtered backprojection (FBP). In this study, the spatial resolution in the entire FOV was determined for the Inveon using FBP, ordered subset expectation maximization in 2 dimensions (OSEM2D) and maximum a posteriori (MAP) reconstructions. OSEM2D produced the best spatial resolution in the axial center of the FOV, but MAP outperformed the two other reconstruction algorithms in terms of uniformity of the resolution.

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Copyright:© 2010 Elsevier
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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