Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption

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Jose, Jithin and Willemink, Rene G.H. and Resink, Steffen and Piras, Daniele and Hespen, J.C.G. van and Slump, Cornelis H. and Steenbergen, Wiendelt and Leeuwen, Ton G. van and Manohar, Srirang (2011) Passive element enriched photoacoustic computed tomography (PER PACT) for simultaneous imaging of acoustic propagation properties and light absorption. Optics Express, 19 (3). pp. 2093-2104. ISSN 1094-4087

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Abstract:We present a ‘hybrid’ imaging approach which can image both light absorption properties and acoustic transmission properties of an object in a two-dimensional slice using a computed tomography (CT) photoacoustic imager. The ultrasound transmission measurement method uses a strong optical absorber of small cross-section placed in the path of the light illuminating the sample. This absorber, which we call a passive element acts as a source of ultrasound. The interaction of ultrasound with the sample can be measured in transmission, using the same ultrasound detector used for photoacoustics. Such measurements are made at various angles around the sample in a CT approach. Images of the ultrasound propagation parameters, attenuation and speed of sound, can be reconstructed by inversion of a measurement model. We validate the method on specially designed phantoms and biological specimens. The obtained images are quantitative in terms of the shape, size, location, and acoustic properties of the examined heterogeneities
Item Type:Article
Additional information:Open access article
Copyright:© 2011 OSA
Faculty:
Science and Technology (TNW)
Electrical Engineering, Mathematics and Computer Science (EEMCS)
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Link to this item:http://purl.utwente.nl/publications/76385
Official URL:http://dx.doi.org/10.1364/OE.19.002093
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