A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography

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Melchels, Ferry P.W. and Feijen, Jan and Grijpma, Dirk W. (2009) A poly(d,l-lactide) resin for the preparation of tissue engineering scaffolds by stereolithography. Biomaterials, 30 (23-24). pp. 3801-3809. ISSN 0142-9612

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Abstract:Porous polylactide constructs were prepared by stereolithography, for the first time without the use of reactive diluents. Star-shaped poly(d,l-lactide) oligomers with 2, 3 and 6 arms were synthesised, end-functionalised with methacryloyl chloride and photo-crosslinked in the presence of ethyl lactate as a non-reactive diluent. The molecular weights of the arms of the macromers were 0.2, 0.6, 1.1 and 5 kg/mol, allowing variation of the crosslink density of the resulting networks. Networks prepared from macromers of which the molecular weight per arm was 0.6 kg/mol or higher had good mechanical properties, similar to linear high-molecular weight poly(d,l-lactide). A resin based on a 2-armed poly(d,l-lactide) macromer with a molecular weight of 0.6 kg/mol per arm (75 wt%), ethyl lactate (19 wt%), photo-initiator (6 wt%), inhibitor and dye was prepared. Using this resin, films and computer-designed porous constructs were accurately fabricated by stereolithography. Pre-osteoblasts showed good adherence to these photo-crosslinked networks. The proliferation rate on these materials was comparable to that on high-molecular weight poly(d,l-lactide) and tissue culture polystyrene
Item Type:Article
Copyright:© 2009 Elsevier Ltd
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/76381
Official URL:http://dx.doi.org/10.1016/j.biomaterials.2009.03.055
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