Biodegradable Elastomeric Networks: Highly Efficient Cross-Linking of Poly(trimethylene carbonate) by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate

Share/Save/Bookmark

Bat, Erhan and Feijen, Jan and Grijpma, Dirk W. (2010) Biodegradable Elastomeric Networks: Highly Efficient Cross-Linking of Poly(trimethylene carbonate) by Gamma Irradiation in the Presence of Pentaerythritol Triacrylate. Biomacromolecules, 11 (10). pp. 2692-2699. ISSN 1525-7797

[img] PDF
Restricted to UT campus only
: Request a copy
443kB
Abstract:Biodegradable elastomeric poly(trimethylene carbonate) (PTMC) networks were efficiently formed by gamma irradiating the linear polymer in the presence of pentaerythritol triacrylate (PETA). The properties of networks formed upon irradiation of PTMC films containing (0, 1, 5 wt %) PETA as a cross-linking aid were evaluated. The gel contents and network densities increased with increasing PETA contents, irradiation dose, and initial polymer molecular weights. At a dose of 25 kGy, networks with gel fractions up to 0.96 could be obtained. The networks were noncytotoxic, had elastic moduli below 10.7 MPa and high tensile strengths of up to 37.7 MPa. The incorporation of PETA also improved the resistance to creep and to tear propagation significantly, resulting in permanent set values that were as low as 0.9% strain and tear strengths up to 9.3 ± 2.0 N/mm. Furthermore, the enzymatic erosion rates of the networks could be decreased from 12.0 ± 2.9 to 3.0 ± 1.6 μm/day. These biodegradable elastomeric PTMC networks may be utilized in a broad range of medical applications
Item Type:Article
Copyright:© 2010 American Chemical Society
Faculty:
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/76324
Official URL:http://dx.doi.org/10.1021/bm1007234
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 271594