Use of 120-nm deep channels for liquid chromatographic separations


Fekete, Veronika and Clicq, David and De Malsche, Wim and Gardeniers, Han and Desmet, Gert (2008) Use of 120-nm deep channels for liquid chromatographic separations. Journal of chromatography A, 1189 (1-2). pp. 2-9. ISSN 0021-9673

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Abstract:The present study reports on the exploration of the separation speed limits of RPLC chromatography in open-tubular channels. Applying the shear-driven chromatography principle in a 120-nm deep open channel, and using an improved detection set-up, the separation of three coumarin dyes was detectable 8 mm downstream of the injection point. At this distance, separation efficiencies of N = 17,900–24,100 plates were obtained at a velocity of 10 mm s−1, corresponding to a plate generation velocity of 21,100 to 28,300 plates per second for the most and least retained component, respectively.
Item Type:Article
Additional information:31st International Symposium on High Performance Liquid Phase Separations and Related Techniques
Copyright: © 2007 Elsevier B.V.
Science and Technology (TNW)
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Metis ID: 247505