Use of 120-nm deep channels for liquid chromatographic separations

Fekete, Veronika and Clicq, David and Malsche de, Wim and Gardeniers, Han and Desmet, Gert (2008) Use of 120-nm deep channels for liquid chromatographic separations. Journal of Chromatography A, 1189 (1-2). pp. 2-9. ISSN 0021-9673

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Abstract:	The present study reports on the exploration of the separation speed limits of RPLC chromatography in open-tubular channels. Applying the shear-driven chromatography principle in a 120-nm deep open channel, and using an improved detection set-up, the separation of three coumarin dyes was detectable 8 mm downstream of the injection point. At this distance, separation efficiencies of N = 17,900–24,100 plates were obtained at a velocity of 10 mm s−1, corresponding to a plate generation velocity of 21,100 to 28,300 plates per second for the most and least retained component, respectively.
Item Type:	Article
Copyright:	© 2007 Elsevier B.V.
Faculty:	Science and Technology (TNW)
Research Group:	Mesoscale Chemical Systems (MCS)
Link to this item:	http://purl.utwente.nl/publications/76301
Official URL:	http://dx.doi.org/10.1016/j.chroma.2007.11.026
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