Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications


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Krishnamoorthy, G. and Carlen, E.T. and Schasfoort, R.B.M. and Berg van den, A. (2010) Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications. In: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010, 3-7 October 2010, Groningen, the Netherlands.

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Abstract:We report a new integrated Lab-on-a-Chip (LOC) and surface plasmon resonance imaging (iSPR) system that uses electrokinetic (EK) sample transport simultaneously into 10 individual microchannels and 100 sensing locations, where all sensing locations can be measured simultaneously and kinetics and affinity parameters extracted from all the interactant pairs. This new chip can be used for high-throughput drug screening applications and the simultaneous extraction of kinetics and affinity parameters from interactant-protein complex formation.
Item Type:Conference or Workshop Item
Faculty:
Electrical Engineering, Mathematics and Computer Science (EEMCS)
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/75862
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