Crosslinked collagen/chitosan matrix for artificial livers


Wang, X.H. and Li, D.P. and Wang, W.J. and Feng, Q.L. and Cui, F.Z. and Xu, Y.X. and Song, X.H. and Werf, Mark van der (2003) Crosslinked collagen/chitosan matrix for artificial livers. Biomaterials, 24 (19). pp. 3213-3220. ISSN 0142-9612

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Abstract:Matrices composed of collagen and chitosan may create an appropriate environment for the regeneration of livers. In this study, we have prepared, characterized and evaluated a new collagen/chitosan matrix (CCM). The CCM was made by using crosslinking agent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) in N-hydroxysuccinimide (NHS) and a 2-morpholinoethane sulfonic acid (MES) buffer system. The chemical characteristics were evaluated by Fourier-transformed infrared (FTIR) spectroscopy and X-ray photoelectron spectroscopy (XPS). The mechanical strength was measured by tensile tests. The platelet deposition and hepatocyte culture experiments show that CCM has excellent blood and cell compatibility. The results suggest that the CCM is a promising candidate matrix for implantable bioartificial livers.
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Copyright:© 2003 Elsevier
Engineering Technology (CTW)
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