Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex

Visser, Sid and Meijer, Hil G.E. and Lee, Hyong C. and Drongelen van, Wim and Putten van, Michel J.A.M and Gils van, Stephan A. (2010) Comparing Epileptiform Behavior of Mesoscale Detailed Models and Population Models of Neocortex. Journal of Clinical Neurophysiology, 27 (6). pp. 471-478. ISSN 0736-0258

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Abstract:	Two models of the neocortex are developed to study normal and pathologic neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons, and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar, synchronized behavior in this detailed model. This observation is captured by a population model that describes the activity of large neuronal populations with two differential equations with two delays. Both models appear to have similar sensitivity to variations of total network excitation. Analysis of the population model reveals the presence of multistability, which was also observed in various simulations of the detailed model.
Item Type:	Article
Copyright:	© 2010 Wolters Kluwer
Faculty:	Electrical Engineering, Mathematics and Computer Science (EEMCS) Science and Technology (TNW)
Research Group:	Applied Analysis and Mathematical Physics (AAMP) Clinical Neurophysiology (CNPH)
Link to this item:	http://purl.utwente.nl/publications/75067
Official URL:	http://dx.doi.org/10.1097/WNP.0b013e3181fe0735
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