Microbubble spectroscopy of ultrasound contrast agents


Meer, Sander M. van der and Dollet, Benjamin and Voormolen, Marco M. and Chin, Chien T. and Bouakaz, Ayache and Jong, Nico de and Versluis, Michel and Lohse, Detlef (2007) Microbubble spectroscopy of ultrasound contrast agents. Journal of the Acoustical Society of America, 121 (1). pp. 648-656. ISSN 0001-4966

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Abstract:A new optical characterization of the behavior of single ultrasound contrast bubbles is presented. The method consists of insonifying individual bubbles several times successively sweeping the applied frequency, and to record movies of the bubble response up to 25 million frames/s with an ultrahigh speed camera operated in a segmented mode. The method, termed microbubble spectroscopy, enables to reconstruct a resonance curve in a single run. The data is analyzed through a linearized model for coated bubbles. The results confirm the significant influence of the shell on the bubble dynamics: shell elasticity increases the resonance frequency by about 50%, and shell viscosity is responsible for about 70% of the total damping. The obtained value for shell elasticity is in quantative agreement with previously reported values. The shell viscosity increases significantly with the radius, revealing a new nonlinear behavior of the phospholipid coating.

Item Type:Article
Copyright:©2007 Acoustical Society of America
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/74989
Official URL:https://doi.org/10.1121/1.2390673
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