Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone

Deschamps, Audrey A. and Claase, Menno B. and Sleijster, Warnerie J. and Bruijn de, Joost D. and Grijpma, Dirk W. and Feijen, Jan (2002) Design of segmented poly(ether ester) materials and structures for the tissue engineering of bone. Journal of Controlled Release, 78 (1-3). pp. 175-186. ISSN 0168-3659

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Abstract:	In this study, PEOT/PBT segmented copolymers of different compositions have been evaluated as possible scaffold materials for the tissue engineering of bone. By changing the composition of PEOT/PBT copolymers, very different mechanical and swelling behaviors are observed. Tensile strengths vary from 8 to 23 MPa and elongations at break from 500 to 1300%. Water-uptake ranges from 4 up to as high as 210%. The in vitro degradation of PEOT/PBT copolymers occurs both by hydrolysis and oxidation. In both cases degradation is more rapid for copolymers with high PEO content. PEOT/PBT scaffolds with varying porosities and pore sizes have been prepared by molding and freeze-drying techniques in combination with particulate-leaching. The most hydrophilic PEOT/PBT copolymers did not sustain goat bone marrow cell adhesion and growth. However, surface modification by gas plasma treatment showed a very much improved polymer–cell interaction for all PEOT/PBT copolymer compositions. Their mechanical properties, degradability and ability to sustain bone marrow cell growth make PEOT/PBT copolymers excellent materials for bone tissue engineering.
Item Type:	Article
Copyright:	© 2002 Elsevier
Faculty:	Science and Technology (TNW)
Research Group:	Biomaterials Science and Technology (BST) Polymer Chemistry and BioMaterials (PBM)
Link to this item:	http://purl.utwente.nl/publications/74695
Official URL:	http://dx.doi.org/10.1016/S0168-3659(01)00497-7
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