Microspheres for protein delivery prepared from amphiphilic multiblock copolymers: 2. Modulation of release rate

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Bezemer, J.M. and Radersma van, R. and Grijpma, D.W. and Dijkstra, P.J. and Blitterswijk van, C.A. and Feijen, J. (2000) Microspheres for protein delivery prepared from amphiphilic multiblock copolymers: 2. Modulation of release rate. Journal of Controlled Release, 67 (2-3). pp. 249-260. ISSN 0168-3659

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Abstract:Amphiphilic multiblock copolymers, based on hydrophilic poly(ethylene glycol) (PEG) blocks and hydrophobic poly(butylene terephthalate) (PBT) blocks were used as matrix material for protein-loaded microspheres. The efficiency of lysozyme entrapment by a double emulsion method was found to depend on the swelling behavior of the polymers in water and decreased from 100% for polymers with a degree of swelling of less than 1.8 to 11% for PEG–PBT copolymers with a degree of swelling of 3.6. The particle size could be controlled by varying the concentration of the polymer solution used in the microsphere preparation. An increase in the polymer concentration resulted in a proportional increase in the particle size. The in vitro release profiles of the encapsulated model protein lysozyme could be precisely tailored by variation of the copolymer composition and the size of the microspheres. Both a slow continuous release of lysozyme, and a fast release which was completed within a few days could be obtained. The release behavior, attributed to a combination of diffusion and polymer degradation, could be described by a previously developed model.
Item Type:Article
Copyright:© 2000 Elsevier
Faculty:
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/74324
Official URL:http://dx.doi.org/10.1016/S0168-3659(00)00212-1
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