Determination of telmisartan in human blood plasma: Part I: Immunoassay development

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Hempen, Christel and Gläsle-Schwarz, Liane and Kunz, Ulrich and Karst, Uwe (2006) Determination of telmisartan in human blood plasma: Part I: Immunoassay development. Analytica Chimica Acta, 560 (1-2). pp. 35-40. ISSN 0003-2670

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Abstract:Telmisartan is an angiotensin II receptor antagonist and a known drug against high blood pressure. In this report, the development of a new and rapid analytical technique, an enzyme-linked immunosorbent assay (ELISA) for the determination of telmisartan in human blood plasma is described. The immunoassay is based on a conversion of 4-(N-methylhydrazino)-7-nitro-2,1,3-benzooxadiazole (MNBDH) to 4-(N-methylamino)-7-nitro-2,1,3-benzooxadiazole (MNBDA), which is detected by fluorescence spectroscopy. The limit of detection was 0.1 ng/mL, the limit of quantification was 0.3 ng/mL and the working range extended from 0.3 ng/mL to 300 ng/mL.

Item Type:Article
Copyright:© 2006 Elsevier B.V
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Link to this item:http://purl.utwente.nl/publications/74291
Official URL:http://dx.doi.org/10.1016/j.aca.2005.12.036
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