Differential SPR immunosensing

Share/Save/Bookmark

Berger, Charles E.H. and Greve, Jan (2000) Differential SPR immunosensing. Sensors and Actuators B: Chemical, 63 (1-2). pp. 103-108. ISSN 0925-4005

[img]PDF
Restricted to UT campus only
: Request a copy
218Kb
Abstract:In this work we describe a surface plasmon resonance (SPR) sensor with a differential detection of the SPR angle, and demonstrate it. The angle of incidence is modulated by a simple piezo-electric actuator, and the reflectance signal is measured with a lockin-amplifier. When the conditions for SPR are fulfilled, the differential signal is zero. The shift of the resonance conditions can be measured as an increase of the differential signal, or using feedback on the angle of incidence. The sensor will be demonstrated by monitoring an adsorption and an immunoreaction at the sensor surface with sub-mdeg. resolution. The modulated incident beam can also be scanned past a number of sensing areas, making multichannel measurements possible, as will be demonstrated.
Item Type:Article
Copyright:© 2000 Elsevier
Research Group:
Link to this item:http://purl.utwente.nl/publications/74263
Official URL:http://dx.doi.org/10.1016/S0925-4005(00)00307-5
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 128419