Nanocavity Redox Cycling Sensors for the Detection of Dopamine Fluctuations in Microfluidic Gradients

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Katelhon, Enno and Hofmann, Boris and Lemay, Serge G. and Zevenbergen, Marcel A.G. and Offenhauser, Andreas and Wolfrum, Bernhard (2010) Nanocavity Redox Cycling Sensors for the Detection of Dopamine Fluctuations in Microfluidic Gradients. Analytical Chemistry, 82 (20). pp. 8502-8509. ISSN 0003-2700

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Abstract:Electrochemical mapping of neurotransmitter concentrations on a chip promises to be an interesting technique for investigating synaptic release in cellular networks. In here, we present a novel chip-based device for the detection of neurotransmitter fluctuations in real-time. The chip features an array of plane-parallel nanocavity sensors, which strongly amplify the electrochemical signal. This amplification is based on efficient redox cycling via confined diffusion between two electrodes inside the nanocavity sensors. We demonstrate the capability of resolving concentration fluctuations of redox-active species in a microfluidic mixing gradient on the chip. The results are explained by a simulated concentration profile that was calculated on the basis of the coupled Navier−Stokes and convection-diffusion equations using a finite element approach.
Item Type:Article
Copyright:© 2010 American Chemical Society
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/73995
Official URL:http://dx.doi.org/10.1021/ac101387f
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