Structural and Viscoelastic Properties of Actin Networks Formed by Espin or Pathologically Relevant Espin Mutants

Share/Save/Bookmark

Lieleg, Oliver and Schmoller, Kurt M. and Purdy Drew, Kirstin R. and Claessens, Mireille M.A.E. and Semmrich, Christine and Zheng, Lili and Bartles, James R. and Bausch, Andreas R. (2009) Structural and Viscoelastic Properties of Actin Networks Formed by Espin or Pathologically Relevant Espin Mutants. ChemPhysChem, 10 (16). pp. 2813-2817. ISSN 1439-4235

[img] PDF
Restricted to UT campus only
: Request a copy
671kB
Abstract:The structural organization of the cytoskeleton determines its viscoelastic response which is crucial for the correct functionality of living cells. Both the mechanical response and microstructure of the cytoskeleton are regulated on a microscopic level by the local activation of different actin binding and/or bundling proteins (ABPs). Misregulations in the expression of these ABPs or mutations in their sequence can entail severe cellular dysfunctions and diseases. Here, we study the structural and viscoelastic properties of reconstituted actin networks cross-linked by the ABP espin and compare the obtained network properties to those of other bundled actin networks. Moreover, we quantify the impact of pathologically relevant espin mutations on the viscoelastic properties of these cytoskeletal networks.
Item Type:Article
Copyright:© 2009 Wiley
Faculty:
Science and Technology (TNW)
Research Group:
Link to this item:http://purl.utwente.nl/publications/72768
Official URL:http://dx.doi.org/10.1002/cphc.200900604
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page

Metis ID: 259575