Water soluble azido polyisocyanopeptides as functional β-sheet mimics


Schwartz, Erik and Koepf, Matthieu and Kitto, Heather J. and Espelt, Mónica and Nebot-Carda, Vicent J. and Gelder, Rene de and Nolte, Roeland J.M. and Cornelissen, Jeroen J.L.M. and Rowan, Alan E. (2009) Water soluble azido polyisocyanopeptides as functional β-sheet mimics. Journal of Polymer Science, Part A: Polymer chemistry, 47 (16). pp. 4150-4164. ISSN 0887-624X

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Abstract:The design and synthesis of functional biomimetic water soluble polymers with a defined secondary structure has been developed using β-sheet polyisocyanopeptide scaffolds. Water soluble isocyanopolymers were prepared by random copolymerisation of the azido functionalized isocyanopeptides with nonfunctionalised methyl ester isocyanides derived from alanine. Upon saponification of the latter function a rigid rod water soluble polymer was obtained with an accessible azide for postfunctionalization. The potential of these biomimetic polymers was successfully demonstrated by using the click chemistry reaction of these polymers with an acetylene functionalised rhodamine dye.
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Copyright:© 2009 Wiley
Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/72751
Official URL:https://doi.org/10.1002/pola.23477
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