Electrochemistry of potentially bioreductive alkylating quinones : Part 1. Electrochemical properties of relatively simple quinones, as model compounds of mitomycin- and aziridinylquinone-type antitumour agents

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Driebergen, R.J. and Hartigh, J. den and Holthuis, J.J.M. and Hulshoff, A. and Oort, W.J. van and Postma Kelder, S.J. and Verboom, W. and Reinhoudt, D.N. and Bos, M. and Linden, W.E. van der (1990) Electrochemistry of potentially bioreductive alkylating quinones : Part 1. Electrochemical properties of relatively simple quinones, as model compounds of mitomycin- and aziridinylquinone-type antitumour agents. Analytica Chimica Acta, 233 . pp. 251-268. ISSN 0003-2670

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Abstract:The influence of methyl-, hydroxy and amino substituents on the electrochemical behaviour of simple 1,4-naphtho-and 1,4-benzoquinones, model compounds of many quinoid antitumour agents, in aqueous media was studied. Significant changes in electrochemical behaviour were observed, potentially the result of a change in the electron density of the quinone moiety, pre- or post-protonation of substituents, hydrogen bond formation, tautomerization reactions and steric interactions between the quinone moiety and substituents. The information obtained was of benefit in the elucidation of the reduction mechanisms of quinoid antitumour agents such as aziridnylquinones and mitomycins.
Item Type:Article
Copyright:© 1990 Elsevier
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/72671
Official URL:http://dx.doi.org/10.1016/S0003-2670(00)83486-8
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