The intensity of the 1602 cm−1 band in human cells is related to mitochondrial activity

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Pully, Vishnu Vardhan and Otto, Cees (2009) The intensity of the 1602 cm−1 band in human cells is related to mitochondrial activity. Journal of Raman Spectroscopy, 40 (5). pp. 473-475. ISSN 0377-0486

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Abstract:We report a Raman band at 1602 cm−1 in the spectra of human cells, which previously had only been observed in mitochondria of yeast cells. This band, which has not yet been assigned to a particular molecular species, was found to occur in HeLa cells, peripheral blood lymphocytes, human mesenchymal stem cells and bovine chondrocytes. The band is proposed as an indicator of the activity of mitochondria in cells. Cells were cultured with and without serum or temporarily deprived of serum. The band can be observed for all these variations in cell culture methodology. The band intensity decreases under the influence of an increase of the calcium ion concentration in the surrounding medium.
Item Type:Article
Copyright:© 2009 Wiley
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Science and Technology (TNW)
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Link to this item:http://purl.utwente.nl/publications/72592
Official URL:http://dx.doi.org/10.1002/jrs.2269
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