Single-Molecule FRET Reveals Structural Heterogeneity of SDS-Bound α-Synuclein

Veldhuis, Gertjan and Segers-Nolten, Ine and Ferleman, Eva and Subramaniam, Vinod (2008) Single-Molecule FRET Reveals Structural Heterogeneity of SDS-Bound α-Synuclein. ChemBioChem, 10 (3). pp. 436-439. ISSN 1439-4227

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Abstract:	SDS-concentration-dependent α-synuclein structure: Upon interaction with SDS, Syn folds into a structure with two antiparallel α-helices. We show from single-molecule FRET that Synn adopts this conformation in an all-or-none fashion below the SDS critical micelle concentration. Population of the folded species is directly coupled to an increase in α-helix content; this suggests that the entire N terminus is involved in the transaction.
Item Type:	Article
Copyright:	© 2008 Wiley
Faculty:	Science and Technology (TNW)
Research Group:	Nano-Biophysics (NBP)
Link to this item:	http://purl.utwente.nl/publications/72559
Official URL:	http://dx.doi.org/10.1002/cbic.200800644
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